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KMID : 0984920080100020038
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Journal of Skin Barrier Research
2008 Volume.10 No. 2 p.38 ~ p.45
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Allergen and skin barrier in atopic disease
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Kim Hyun-Jung
Jeong Se-Kyoo
Lee Seung-Hun
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Abstract
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Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with a complex interplay between multiple factors, such as 1> strong genetic factors 2> the cutaneous hyperreactivity to environmental trigger 3> neurologic and pharmacologic dysfunction 4> underlying defect in skin barrier function. Various contact allergens and aero allergens are focused as the important factors for the initiation of atopic diseases, aggravation of the diseases and therapeutic targets. In this review, the role of allergens in atopic disease can be explained in the view of various proteases, chitinase, abnormal skin barrier function and finally the vicious relationship with inflammation.
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KEYWORD
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atopic dermatitis, Th1/2 imbalance, skin barrier, "outside-inside-outside" model, allergen, protease, PAR2, chitinase
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